Publication: Coevolution of mitochondrial and somatic nuclear DNA mutations.

A satisfying conclusion to a side-story that became a major project of Livius’ postdoc with Cathy Wu.

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We show co-evolution of mitochondrial and somatic nuclear DNA mutations using various approaches including reanalysis of bulk RNA and WES-seq data, single cell DNA sequencing and ASAP-seq. Further, we use maternal mitochondrial DNA variants to track rare donor or recipient-derived single cells following allogeneic stem cell transplantation to map out microchimeric states, such as residual leukemia at incipient relapse or remaining donor-derived hematopoiesis at time of frank hematologic recurrence.